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First, the sulfonation reaction saturates and that allows more NAPQI to accumulate ([7, 24]) and second, the increased amount of NAPQI exhausts the liver stores of reduced glutathione (GSH)[6] as well as the livers capacity to synthesize new GSH

Chen H, Dunk MM, Wang B, Zhao M, Shen J, Zong G, et al

8 Kidney disease Semaglutide was tested in a double blind, placebo-controlled trial that enrolled people with both type 2 diabetes and chronic kidney disease